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Biotech startup Ribometrix raises $3.5M, wants $7M

Oct, 12 2017, 7:34 AM

Ribometrix, a Greenville-based startup that pitched investors at the CED Life Science conference earlier this year, has secured $3.5 million in new financing. And the company wants more.

The funding was disclosed in a securities filing.

The startup has already received support from the North Carolina Biotechnology Center and the National Institutes of Health. Its focus is developing new drugs based on ribonucleic acid, or RNA, structures.

"Novel small molecule therapies that target underlying disease mechanisms are desperately needed for high-unmet, rare/orphan as well as broader population diseases such as Huntington’s Disease, cancer, fibrosis, MS, others" the company says.

"Targeting RNAs to treat these diseases has been of huge interest, however thus far RNAs have only partially been targeted with oligonucleotides (antisense, siRNA, microRNA) due to lack of systematic small molecule screening and design/SAR tools against RNA."

Kevin Weeks, the firm's vice president and co-founder, is a professor at UNC-Chapel Hill where RNA structure and function as well as RNA therapeutics are key areas of his research.

The company was founded in 2015 with an exclusive license to a pair of high throughput platforms developed by Weeks. In 2011, The NIH awarded Weeks a four-year grant to work on drugs that bind to RNA.

Cambridge, Massachusetts-based messenger RNA drug developer Moderna has pumped $100,000 into the startup.

Ribometrix disclosed that the latest investment would go toward working capital, which could include executive compensation. The funds were raised through 10 investors, with a $10,000 minimum investment.

Here's a look at the company:


Ribometrix

COMPANY PROFILE

Ribometrix is discovering small molecule therapeutics for rare/orphan and unmet human diseases targeting RNAs using its proprietary disruptive RNA platform technologies.

Unmet need: RNAs have been of huge interest and represent a broad avenue to impact a large class of targets. Thus far, RNAs have only partially been targeted with oligonucleotides (antisense, siRNA, microRNA) due to a lack of systematic small molecule screening capabilities and design/SAR tools against RNA.
Disruptive Solution: Using its validated platforms, Ribometrix can first systematically discover druggable 3D structures in RNAs (no other drug discovery approach can achieve this robustly and rapidly at a reasonable cost). Second, Ribometrix can perform compound screening to find hit molecules, defining their mode of interaction and providing a specificity assessment in a single assay.

With these platforms, Ribometrix is enabling the rapid discovery of high confidence hits to progress into traditional lead optimization to design drug-like molecules (assets) for Huntington’s Disease, cancer, fibrosis, MS and other high-unmet, rare/orphan as well as broader population diseases.

FOUNDERS/MANAGEMENT TEAM

KEY MILESTONES TO DATE

Q&A

Novel small molecule therapies that target underlying disease mechanisms are desperately needed for high-unmet, rare/orphan as well as broader population diseases such as Huntington’s Disease, cancer, fibrosis, MS etc.

Targeting RNAs to treat these diseases has been of huge interest, however thus far RNAs have only partially been targeted with oligonucleotides (antisense, siRNA, microRNA) due to lack of systematic small molecule screening and design/SAR tools against RNA.

What sets your company apart? What's the "secret sauce"?

Secret sauce is Ribometrix’ disruptive MaP Technologies plus Ribometrix’ scientific team. Ribometrix’s disruptive MaP Technologies systematically discover druggable 3D structures in RNAs.

No other drug discovery approach can achieve this robustly and rapidly in reasonable costs. Ribometrix scientific team has significant know-how and experience in implementing these disruptive technologies in high-through RNA-based drug discovery.

This enables rapid discovery and design of drug-like molecules (assets) for Huntington’s, cancer, fibrosis, MS and other high-unmet, rare/orphan as well as broader population diseases.

Investors should be in interested in participating in Ribometrix for its disruptive technology and its potential to develop high value therapies for many unmet diseases. Some of the small molecule therapeutic assets will be progressed by Ribometrix into clinical and commercial development and some of the assets will be licensed to pharma/biotech for development and commercialization.

Having a rich pipeline of therapeutic products (some internal, some partnered) will position the company for acquisition by large pharma or an exit via IPO in the future.

Ribometrix potential products are expected to address a broad range of disease markets, including cancer, fibrosis, multiple sclerosis, liver diseases, Huntington’s disease.

Considering the patient population numbers and unmet needs in these diseases, we believe the total market size could be in the wide range of $5-50 billion. In addition to the value of the potential products, Ribometrix will generate revenue (upfront and milestone payments) from its platform partnerships with large pharmaceutical and biotech companies.


Note: North Carolina Business News Wire contributed to this report.





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